Hypromellose Acetate Succinate (HPMCAS)

Pharmaceutical Excipient for Enteric Coating and Drug Solubility Enhancement

Hypromellose Acetate Succinate (HPMCAS), also known as Hydroxypropyl Methylcellulose Acetate Succinate, is a cellulose-based pharmaceutical polymer widely used as a functional excipient in oral drug formulations.

HPMCAS is a chemically modified cellulose derivative containing methoxy, hydroxypropyl, acetyl, and succinoyl groups. Its pH-dependent solubility makes it particularly suitable for enteric coating and delayed-release pharmaceutical formulations.

In addition to its use as an enteric coating polymer, HPMCAS is widely used in amorphous solid dispersions (ASDs) to improve the apparent solubility and dissolution performance of poorly water-soluble active pharmaceutical ingredients (APIs).

With its versatile film-forming properties and formulation flexibility, Hypromellose Acetate Succinate is an important pharmaceutical excipient for developing advanced oral drug delivery systems.

Key Features and Benefits

1. pH-Dependent Solubility

HPMCAS exhibits pH-dependent dissolution behavior, making it suitable for pharmaceutical formulations designed for intestinal release.

2. Excellent Enteric Coating Applications

It can be used as an enteric coating polymer for tablets, granules, and other oral dosage forms to help protect acid-sensitive ingredients from gastric conditions.

3. Drug Solubility Enhancement

HPMCAS is widely used as a carrier polymer in amorphous solid dispersions to improve the apparent solubility and dissolution of poorly water-soluble drugs.

4. Film-Forming Properties

Its film-forming characteristics make it suitable for developing enteric-coated and delayed-release pharmaceutical dosage forms.

5. Multiple Grade Options

Different HPMCAS grades offer different dissolution pH characteristics and particle size distributions, allowing formulators to select suitable materials according to formulation requirements.

Pharmaceutical Applications

Hypromellose Acetate Succinate is commonly used in:

• Enteric coating for tablets and granules.

• Delayed-release oral pharmaceutical formulations.

• Amorphous solid dispersions (ASDs).

• Solubility enhancement of poorly water-soluble APIs.

• pH-dependent drug delivery systems.

• Pharmaceutical film coating applications.

Product Information

• Product Name: Hypromellose Acetate Succinate

• Abbreviation: HPMCAS

• Chemical Name: Hydroxypropyl Methylcellulose Acetate Succinate

• CAS Number: 71138-97-1

• Product Category: Pharmaceutical Excipient

• Functional Categories: Enteric Coating Agent, Film-Forming Agent, Solubility Enhancing Agent, and Controlled-Release Polymer.

Cas No.: 71138-97-1        HS Code: 39129000

Main Purpose: Enteric coating material.

Package: 25kg/fiber drum

Packing Size: D46cm*H52cm

G.W.: 29kg 

Why Choose Hypromellose Acetate Succinate?

HPMCAS offers pharmaceutical formulators a versatile polymer for developing enteric-coated, delayed-release, and solubility-enhanced oral dosage forms.

Its pH-dependent dissolution properties and compatibility with different formulation technologies make it a valuable material for modern pharmaceutical development.

Looking for Hypromellose Acetate Succinate (HPMCAS) for your pharmaceutical formulations? Contact us to discuss product specifications, available grades, and supply requirements.

FAQs

Q1: What is Hypromellose Acetate Succinate (HPMCAS)?

Hypromellose Acetate Succinate (HPMCAS) is a cellulose-based pharmaceutical polymer derived from hypromellose (HPMC). It contains acetyl and succinoyl groups and is widely used as an enteric coating agent, film-forming polymer, and carrier for amorphous solid dispersions.

Q2: What is the CAS number of Hypromellose Acetate Succinate?

The CAS number of Hypromellose Acetate Succinate is 71138-97-1. It is also commonly abbreviated as HPMCAS.

Q3: What is HPMCAS used for in pharmaceutical manufacturing?

HPMCAS is mainly used for enteric coating, delayed-release formulations, and amorphous solid dispersions. It also serves as a functional polymer for improving the apparent solubility and dissolution performance of poorly water-soluble drugs.

Q4: How does HPMCAS work as an enteric coating polymer?

HPMCAS has pH-dependent solubility. It remains relatively insoluble under acidic gastric conditions and dissolves at higher pH levels, depending on its grade. This property makes it useful for developing oral dosage forms designed for intestinal release.

Q5: Can HPMCAS improve the solubility of poorly water-soluble drugs?

Yes. HPMCAS is widely used as a carrier polymer in amorphous solid dispersions (ASDs). It can help maintain drugs in an amorphous state and inhibit recrystallization, improving apparent solubility and dissolution performance.

Q6: What are the different grades of HPMCAS?

HPMCAS is commonly available in Low (L), Medium (M), and High (H) grades, which differ in their chemical substitution and pH-dependent dissolution characteristics. Fine (F) and Granular (G) versions may also be available, depending on the manufacturer.

Q7: What is the difference between HPMCAS and HPMCP?

HPMCAS (Hypromellose Acetate Succinate) contains acetyl and succinoyl groups, while HPMCP (Hypromellose Phthalate) contains phthalyl groups. Both are cellulose-based pharmaceutical polymers used for enteric coating, but they have different chemical structures and formulation characteristics.

Q8: Is HPMCAS suitable for tablet coating?

Yes. HPMCAS can be used as an enteric coating material for tablets and granules. Its pH-dependent dissolution properties help develop dosage forms designed to resist acidic gastric conditions.

Q9: What factors should be considered when selecting an HPMCAS grade?

Important factors include the target dissolution pH, API characteristics, desired drug-release profile, particle size, coating process, and formulation compatibility. The appropriate grade should be selected based on formulation development and dissolution testing.

Q10: How should Hypromellose Acetate Succinate be stored?

HPMCAS should generally be stored in tightly closed containers in a cool and dry environment, protected from excessive moisture. Always follow the manufacturer's recommended storage conditions and product specifications.