FL-500D GMP Compliant Fluid Bed Granulator with Integrated Mixing Granulation & Drying

1 Product Overview

FBD Referenced Photos

2 Application

The FL fluid bed granulator is a pharmaceutical-grade equipment integrating mixing, granulation and drying functions in a GMP-compliant, dead-space-free design with polished surfaces, operating under negative pressure for containment. It serves pharmaceutical (including TCM), food and chemical applications.

3 Work principle

The fluid bed granulator consists of a main machine, spraying module, air inlet module, air exhaust module, and control system. Material is loaded into the material chamber. Process air undergoes primary filtration, medium filtration, dehumidification (Option), heating, and HEPA filtration in the air inlet module before entering the main machine.The conditioned air passes through an air distribution plate to achieve uniform velocity for material fluidization. Binder liquid is delivered via a peristaltic pump to spray nozzles, atomized, and continuously coated onto fluidized particles to promote agglomeration. Simultaneous drying with heated air forms granules.

During granulation, fine powder entrained in the airflow is filtered by dust bags in the dedusting module and discharged through the air exhaust module. Post-granulation, discharge is achievable via manual operation, lifting-tilting granulator, or vacuum discharger through a closed connection with a lifting vacuum granulator.

4 Features

1) Utilizing PID control with Siemens proportional valves, the air temperature is adjustable from ambient to 120°C. With stable steam supply and proper steam traps, temperature stability is maintained within ±2°C of setpoint to prevent fluctuations and enhance production stability.

2) The system achieves 11 g/kg inlet humidity via coil dehumidification. Optional desiccant wheel reduces humidity to 5–8 g/kg, with an oversized wheel option achieving 3–4 g/kg and dual-wheel systems maintain humidity ≤1 g/kg

3) Air handling system: Standard G4 pre-filter + F8 medium filter + H13 HEPA (with DOP test port for integrity testing).

4) Differential pressure gauges on primary/intermediate filters monitor clogging; HEPA differential pressure analog signal displays on HMI.

5) Proportional valve controls negative pressure to prevent bed collapse.

6) Tapered expansion chamber with multi-height spray nozzles.

7) Optimized distribution plate ensures uniform airflow and granule size distribution.

8) Upgraded PTD-3D antistatic filter bags: Non-stick, high permeability, cleanable.

9) Top-mounted directional explosion vent protects pressure-sensitive components.

10) Secondary dust filtration: F9 (<20 mg/m³). Options: F9+H13: <10 mg/m³, F9+H14:<1 mg/m³

11) ATEX-certified centrifugal blower maintains stable airflow/pressure

12) Optional CIP system cleans Bottom chamber, product container, fluidized chamber, and filter housing

13) Recipe-driven automation for production/cleaning cycles with customizable parameters.

14) Five-tier password control: Monitor/Operator/Technician/Maintenance/Admin.

15) Airflow control accuracy: ±5%; Supports audit trail, data logging, and printing.

16) Moisture-based endpoint detection for granulation.

17) CE compliant (EU Machinery Directive 2006/42/EC).

5 Innovative Design

The air distribution plate, a critical component in fluidized bed systems, supports the material bed and ensures uniform gas distribution. Parameters including aperture size, shape, configuration, and open area ratio determine airflow path, velocity, and temperature distribution. Optimization from cylindrical holes to a swirl-hole pattern (illustrated below) enhances these parameters.

6 Main Technical parameter